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The college football season is in full swing, and the battle for Southeastern Conference supremacy is heating up.
In a game between ranked SEC opponents, No. 22 Missouri will be at home Saturday to host the No. 24 South Carolina Gamecocks in Columbia, Missouri.
We have everything you need to know about the matchup, including the kickoff time, betting odds and TV info, as well as the recent results and future schedules for Missouri and South Carolina.
Don’t miss a second of SEC action in Week 4! And be sure to check back all season long for the latest updates on college football’s marquee matchups.
Watch South Carolina vs. Missouri live with Fubo
What time does the South Carolina-Missouri college football game start Sept. 20?
The South Carolina Gamecocks and Missouri Tigers will play at 7 p.m. ET Sept. 20, 2025.
Where is the South Carolina-Missouri college football game happening Sept. 20?
South Carolina and Missouri will kick off from Faurot Field at Memorial Stadium in Columbia, Missouri.
Where to watch South Carolina-Missouri college football game on Sept. 20
The game will air on ESPN and can be streamed live on Fubo.
Watch South Carolina vs. Missouri with Fubo!
Betting odds for South Carolina-Missouri game on Sept. 20
Missouri is a 9.5-point favorite over South Carolina. Over/Under: 48.5 points
College football odds courtesy of BetMGM Sportsbook. For a full list of updated sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Missouri Tigers record, most recent results
Missouri is 3-0 and most recently defeated Louisiana 52-10 on Sept. 13.
South Carolina Gamecocks record, most recent results
South Carolina is 2-1 and most recently lost to Vanderbilt 31-7 on Sept. 13.
Missouri football schedule: next three Tigers games
UMass (Sept. 27, home), Alabama (Oct. 11, home), Auburn (Oct. 18, away)
South Carolina football schedule: next three Gamecocks games
Kentucky (Sept. 27, home), LSU (Oct. 11, away), Oklahoma (Oct. 18, home)
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